Welcome to the new version of CaltechAUTHORS. Login is currently restricted to library staff. If you notice any issues, please email coda@library.caltech.edu
Published March 11, 2009 | Published
Journal Article Open

Hyperpolarized ^1H NMR employing low γ nucleus for spin polarization storage


The PASADENA (parahydrogen and synthesis allow dramatically enhanced nuclear alignment)(1, 2) and DNP (Dynamic Nuclear Polarization)(3) methods efficiently hyperpolarize biologically relevant nuclei such as 1^H, (31)^P, (13)^C, (15)^N achieving signal enhancement by a factor of ~ 100000 on currently utilized MRI scanners. Recently, many groups have demonstrated the utility of hyperpolarized MR in biological systems using hyperpolarized (13)^C biomarkers with a relatively long spin lattice relaxation time T_1 on the order of tens of seconds.(4-7) Moreover, hyperpolarized (15)^N for biomedical MR has been proposed due to even longer spin lattice relaxations times.(8) An additional increase of up to tens of minutes in the lifetime of hyperpolarized agent in vivo could be achieved by using the singlet states of low gamma (γ) nuclei.(9) However, as NMR receptivity scales as γ^3 for spin 1/2 nuclei, direct NMR detection of low γ nuclei results in a lower signal-to-noise ratio compared to proton detection. While protons are better nuclei for detection, short spin lattice relaxation times prevent direct 1^H hyperpolarized MR in biomedical applications.

Additional Information

© 2009 American Chemical Society. ACS AuthorChoice. Publication Date (Web): February 16, 2009. Received December 9, 2008. We thank Drs. Brian D. Ross and William H. Perman and the following for funding: NIH 1K99CA134749-01, R01 CA 122513, 1R21 CA118509, Rudi Schulte Research Institute, James G. Boswell Fellowship, AHA, American Brain Tumor Association, Beckman Institute, Tobacco Related Disease Research Program 16KT-0044, Prevent Cancer Foundation.

Attached Files

Published - Chekmenev2009p1672J_Am_Chem_Soc.pdf


Files (574.8 kB)
Name Size Download all
574.8 kB Preview Download

Additional details

August 20, 2023
October 18, 2023