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Published November 2010 | Erratum + Published
Journal Article Open

Spectral hole burning for ultrasound-modulated optical tomography of thick tissue


We apply spectral hole burning (SHB)-aided detection in ultrasound-modulated optical tomography (UOT) to image optical heterogeneities in thick tissue-mimicking phantom samples and chicken breast tissue. The efficiency of SHB is improved by using a Tm^(3+):YAG crystal of higher doping concentration (2.0-atomic%) and a double-pass pumping configuration, in which the pump beam is transmitted through the crystal twice to burn a deeper spectral hole with the available optical intensity. With the improved SHB-UOT system, we image absorbing, scattering, and phase objects that are embedded in the middle plane of a 30-mm-thick phantom sample. The imaging resolution was 0.5 mm in the lateral direction, as defined by the focal width of the ultrasonic transducer, and 1.5 mm in the axial direction, as determined by the ultrasonic burst length. We also image two absorbing objects embedded in a 32-mm-thick chicken breast sample. The results suggest that the improved SHB-UOT system is one step closer to the practical optical imaging application in biological and clinical studies.

Additional Information

© 2010 SPIE. Paper 10488LR received Sep. 1, 2010; revised manuscript received Sep. 28, 2010; accepted for publication Sep. 29, 2010; published online Dec. 13, 2010; corrected Dec. 16, 2010. We are thankful to Chulhong Kim for his assistance with an early system setup. This research is funded in part by the National Institutes of Health grants R01 EB000712 and U54 CA136398..

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Published - 066018_1.pdf

Erratum - 069801_1.pdf


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