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Published February 22, 2012 | Supplemental Material + Accepted Version
Journal Article Open

A Facile and General Method for the Encapsulation of Different Types of Imaging Contrast Agents Within Micrometer-Sized Polymer Beads


Polystyrene (PS) hollow beads with holes on the surfaces are employed as containers for quick loading and encapsulation of a variety of contrast enhancement agents: saline solutions for thermoacoustic tomography, iodinated organic compounds for micro-computed tomography, and perfluorooctane for magnetic resonance. Because of the hole on the surface of the PS hollow bead, the contrast agent to be encapsulated could quickly enter the hollow interior via direct flow rather than slow diffusion through the wall. After loading, the hole on the surface is conveniently sealed by annealing the sample at a temperature (e.g., 95 °C) slightly above the glass-transition temperature of PS. In vitro methods are also used to investigate the effectiveness of encapsulation by quantifying the contrast enhancement enabled by the contrast agents.

Additional Information

© 2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. Received: October 26, 2011; Published online: December 12, 2011. M.Y.B. and C.H.M. contributed equally to this work. This work was supported in part by an NIH Director's Pioneer Award (5DP1 OD000798) and start-up funds from Washington University in St. Louis. Part of the research was performed at the Nano Research Facility, a member of the National Nanotechnology Infrastructure Network (NNIN), which is supported by the NSF under award no. ECS-0335765. M.Y.B. acknowledges a fellowship supported by the Taiwan Merit Scholarship program (NSC-095-SAF-I-564-620-TMS).

Attached Files

Accepted Version - nihms-1060475.pdf

Supplemental Material - adfm_201102582_sm_suppl.pdf


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