Photoacoustic tomography through a whole adult human skull with a photon recycler
Photoacoustic tomography (PAT) of the human brain is challenging due to the fact that the skull strongly absorbs and scatters light, and attenuates and distorts ultrasound as well. For the first time, we demonstrated the feasibility of PAT through a whole adult human skull. A photon recycler (PR) was built to increase light transmittance through the skull. Both a graphite target and a canine brain were imaged through the skull. Use of the PR was found to improve the photoacoustic signal-to-noise ratio by a factor of 2.4. In addition, subtraction of photoacoustic signals that arise from light absorption within the skull significantly improved the contrast of the target. Our results indicate that PAT can potentially be applied to in vivo human brain imaging.
Additional Information© 2012 SPIE. Paper 12630L received Sep. 22, 2012; revised manuscript received Oct. 16, 2012; accepted for publication Oct. 17, 2012; published online Nov. 2, 2012. We thank Ms. Sandra Matteucci for the close manuscript proofreading. We acknowledge support by the NIH awards R01 EB010049, R01 CA134539, R01 EB000712, U54 CA136398, and R01 EB008085. L. V. W. has a financial interest in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work.
Published - JBO_17_11_110506.pdf