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Published December 2002 | public
Journal Article

Photoacoustic tomography of biological tissues with high cross-section resolution: Reconstruction and experiment

Abstract

A modified back-projection approach deduced from an exact reconstruction solution was applied to our photoacoustic tomography of the optical absorption in biological tissues. Pulses from a Ti:sapphire laser (4.7 ns FWHM at 789.2 nm) were employed to generate a distribution of photoacoustic sources in a sample. The sources were detected by a wide-band nonfocused ultrasonic transducer at different positions around the imaging cross section perpendicular to the axis of the laser irradiation. Reconstructed images of phantoms made from chicken breast tissue agreed well with the structures of the samples. The resolution in the imaging cross section was experimentally demonstrated to be better than 60 μm when a 10 MHz transducer (140% bandwidth at −60 dB) was employed, which was nearly diffraction limited by the detectable photoacoustic waves of the highest frequency.

Additional Information

© 2002 American Association of Physicists in Medicine. Received 26 December 2001; accepted for publication 25 September 2002; published 27 November 2002. This project was sponsored in part by the U.S. Army Medical Research and Material Command Grant No. DAMD 17-00-1-0455, the National Institutes of Health Grant No. R01 CA71980, the National Science Foundation Grant No. BES-9734491, Texas Higher Education Coordinating Board Grant No. ARP 000512-0123-1999, and the Robert A. Welch Foundation Grant No. A-1218.

Additional details

Created:
August 19, 2023
Modified:
October 24, 2023