Molecular biology of embryonic development: How far have we come in the last ten years?
The successes of molecular developmental biology over the last ten years have been particularly impressive in those directions favored by its major paradigms. New technologies have both guided and been guided by the progress of the field. I review briefly some of the major insights into embryonic development that have derived from research in four specific areas: early embryogenesis of various forms; "pattern formation"; evolutionary conservation of regulatory elements; and spatial mechanisms of gene regulation. There remain many major problem areas, some of which may require new orientations to solve.
© 1994 Cambridge University Press. I am deeply indebted to Roy Britten, Andy Cameron, Scott Fraser, Mike Levine, Ellen Rothenberg, and Jim Strauss for their perspicacious and insightful assistance with drafts of this manuscript. I could not have prepared this essay without the knowledgable bibliographic expertise of Jane Rigg.