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Published April 6, 2011 | Supplemental Material + Accepted Version
Journal Article Open

A New Theranostic System Based on Gold Nanocages and Phase-Change Materials with Unique Features for Photoacoustic Imaging and Controlled Release


This communication reports a new theranostic system with a combination of capabilities to both enhance the contrast of photoacoustic (PA) imaging and control the release of a chemical or biological effector by high-intensity focused ultrasound (HIFU). The fabrication of this system simply involves filling the hollow interiors of gold nanocages with a phase-change material (PCM) such as 1-tetradecanol that has a melting point of 38−39 °C. The PCM can be premixed and thus loaded with a dye, as well as other chemical or biological effectors. When exposed to direct heating or HIFU, the PCM will melt and escape from the interiors of nanocages through small pores on the surface, concurrently releasing the encapsulated molecules into the surrounding medium. We can control the release profile by varying the power of HIFU, the duration of exposure to HIFU, or both.

Additional Information

© 2011 American Chemical Society. Received: January 28, 2011; Published: March 14, 2011. This work was supported in part by a 2006 NIH Director's Pioneer Award (DP1 OD000798), startup funds from Washington University in St. Louis, and the World Class University (WCU) program at Yonsei University. Part of the work was done at the Nano Research Facility (NRF), a member of the National Nanotechnology Infrastructure Network (NINN), which is supported by the NSF under award no. ECS-0335765.

Attached Files

Accepted Version - nihms280787.pdf

Supplemental Material - ja200894u_si_001.pdf


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