Resource
Peripheral neuronal activation shapes the
microbiome and alters gut physiology
Graphical abstract
Highlights
d
ChAT
+
and TH
+
neurons show distinct spatial organization
within the ENS of mice
d
ChAT
+
and TH
+
neurons differentially shape the composition
of the gut microbiome
d
Gut-associated TH
+
neurons regulate fungal colonization of
the gut
d
Gut-associated ChAT
+
neuron activation promotes fluid
secretion and colonic motility
Authors
Jessica A. Griffiths, Bryan B. Yoo,
Peter Thuy-Boun, ..., Rob Knight,
Viviana Gradinaru, Sarkis K. Mazmanian
Correspondence
sarkis@caltech.edu
In brief
Griffiths et al. examine how activating
ChAT
+
or TH
+
gut-associated neurons
shapes the gut microbiome and
physiology in mice. They uncover unique
alterations in the metagenome,
transcriptome, metabolome, and
proteome, as well as GI motility,
suggesting that subpopulations of
peripherally activated neurons
differentially regulate the gut microbiome
and GI function with no involvement of
signals from the brain.
Griffiths et al., 2024, Cell Reports
43
, 113953
April 23, 2024
ª
2024 The Author(s).
https://doi.org/10.1016/j.celrep.2024.113953
ll