CaltechAUTHORS
Published January 18, 2017 | Version Accepted Version
Journal Article Open

NMR Hyperpolarization Techniques of Gases

Creators

  • 1. ROR icon Huazhong University of Science and Technology
  • 2. ROR icon Southern Illinois University System
  • 3. ROR icon University of North Carolina at Chapel Hill
  • 4. ROR icon California Institute of Technology
  • 5. ROR icon University of Oulu
  • 6. ROR icon International Tomography Center
  • 7. ROR icon Novosibirsk State University
  • 8. ROR icon Boreskov Institute of Catalysis
  • 9. ROR icon Massachusetts General Hospital
  • 10. ROR icon Queen's Medical Centre
  • 11. ROR icon University of Nottingham
  • 12. ROR icon Leibniz-Forschungsinstitut für Molekulare Pharmakologie
  • 13. ROR icon Russian Academy of Sciences

Abstract

Nuclear spin polarization can be significantly increased through the process of hyperpolarization, leading to an increase in the sensitivity of nuclear magnetic resonance (NMR) experiments by 4-8 orders of magnitude. Hyperpolarized gases, unlike liquids and solids, can be more readily separated and purified from the compounds used to mediate the hyperpolarization processes. These pure hyperpolarized gases enabled many novel MRI applications including the visualization of void spaces, imaging of lung function, and remote detection. Additionally, hyperpolarized gases can be dissolved in liquids and can be used as sensitive molecular probes and reporters. This mini-review covers the fundamentals of the preparation of hyperpolarized gases and focuses on selected applications of interest to biomedicine and materials science.

Additional Information

© 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. Issue online: 20 January 2017; Version of record online: 5 December 2016; Accepted manuscript online: 6 October 2016; Manuscript Received: 14 August 2016. The Hyperpolarised Lung Function Imaging Facility (HILF), within the Sir Peter Mansfield Magnetic Imaging Centre (SPMIC) at University of Nottingham, where the M.J.B, SS and IPH undertake research into novel functional MRI techniques, is the beneficiary of grants provided by UK's Medical Research Council (MRC) and Engineering and Physical Sciences Research Council (EPSRC). MGS thanks Burroughs Wellcome Fund Career Award at the Scientific Interface, Human Frontiers Science Program # RGP0050, and Heritage Medical Research Institute for funding. AMC thanks NIH 1F32EB021840 career award. We thank the following award for funding support: NSF CHE-1416268 and CHE-1416432 (EYC, BMG, IVK, KVK), NIH 1R21EB018014 and 1R21EB020323 (EYC and BMG), DOD CDMRP BRP W81XWH-12-1-0159/BC112431 (EYC), PRMRP W81XWH-15-1-0271 and W81XWH-15-1-0272 (EYC, MSR, BMG), ExxonMobil Research and Engineering Company Knowledge Build (EYC). KVK, VVZ and IVK thank the Russian Science Foundation (grant 14–35–00020) for support of the MRI experiments. V.-V.T. acknowledges the Academy of Finland (grant numbers 289649 and 294027) for the financial support. Part of this work has been supported by the European Research Council under the European Community's Seventh Framework Programme (FP7/2007-2013)/ERC grant agreement no. 242710 to L.S.) and the Leibniz Association (WGL; grant SAW-2011-FMP-2 to L.S.).

Attached Files

Accepted Version - chem201603884.pdf

Accepted Version - nihms855956.pdf

Files

chem201603884.pdf

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Additional details

Identifiers

PMCID
PMC5462469
Eprint ID
71215
DOI
10.1002/chem.201603884
Resolver ID
CaltechAUTHORS:20161018-095718409

Related works

Describes
10.1002/chem.201603884 (DOI)

Funding

Medical Research Council (MRC)
Engineering and Physical Sciences Research Council (EPSRC)
Burroughs Wellcome Fund
Human Frontiers Science Program
RGP0050
Heritage Medical Research Institute
NIH
1F32EB021840
NSF
CHE-1416268
NSF
CHE-1416432
NIH
1R21EB018014
NIH
1R21EB020323
Department of Defense (DOD)
CDMRP BRP W81XWH-12-1-0159/BC112431
Peer Reviewed Medical Research Program (PRMRP)
W81XWH-15-1-0271
Peer Reviewed Medical Research Program (PRMRP)
W81XWH-15-1-0272
ExxonMobil Research and Engineering Company
Russian Science Foundation
14-35-00020
Academy of Finland
289649
Academy of Finland
294027
European Research Council (ERC)
242710
Leibniz Association
SAW-2011-FMP-2

Dates

Created
2016-10-18
Created from EPrint's datestamp field
Updated
2022-04-07
Created from EPrint's last_modified field

Caltech Custom Metadata

Caltech groups
Heritage Medical Research Institute