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Published July 26, 2017 | Published
Journal Article Open

Multiview Hilbert transformation in full-ring transducer array-based photoacoustic computed tomography


Based on the photoacoustic (PA) effect, PA tomography directly measures specific optical absorption, i.e., absorbed optical energy per unit volume. We recently developed a full-ring ultrasonic transducer array-based photoacoustic computed tomography (PACT) system for small-animal whole-body imaging. The system has a full-view detection angle and high in-plane resolution (∼100  μm). However, due to the bandpass frequency response of the piezoelectric transducer elements and the limited elevational detection coverage of the full-ring transducer array, the reconstructed images present bipolar (i.e., both positive and negative) pixel values, which cause ambiguities in image interpretation for physicians and biologists. We propose a multiview Hilbert transformation method to recover the unipolar initial pressure for full-ring PACT. The effectiveness of the proposed algorithm was first validated by numerical simulations and then demonstrated with ex vivo mouse brain structural imaging and in vivo mouse whole-body imaging.

Additional Information

© 2017 SPIE. Paper 170157RR received Mar. 13, 2017; accepted for publication Jul. 12, 2017; published online Jul. 26, 2017. The authors appreciate the close reading of the paper by Professor James Ballard. We also thank Guo Li and Jun Xia for technical support and helpful discussions. This work was sponsored by the National Institutes of Health Grants DP1 EB016986 (NIH Director's Pioneer Award), R01 CA186567 (NIH Director's Transformative Research Award), R01 EB016963, U01 NS090579 (NIH BRAIN Initiative), and U01 NS099717 (NIH BRAIN Initiative).

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August 19, 2023
October 26, 2023