Welcome to the new version of CaltechAUTHORS. Login is currently restricted to library staff. If you notice any issues, please email coda@library.caltech.edu
Published May 5, 1989 | public
Journal Article

Protein phosphorylation in chemotaxis and two-component regulatory systems of bacteria


Two-component regulatory systems appear to be widespread in bacteria. Phosphorylation has been demonstrated in three of the known systems and correlated with in vivo function in two cases (Che and Ntr). Although phosphorylation of sensor and regulator proteins has so far been observed exclusively in vitro, transient protein phosphorylation could provide a basis for the mechanism of signal transduction in these bacterial systems. There is currently insufficient evidence, however, to establish the precise functional relationship(s) between the conserved sensor and regulator sequences, phosphorylation, and the detailed mechanism involved in signal transduction via the sensor and regulator proteins.

Additional Information

© 1989 by The American Society of Biochemistry and Molecular Biology, Inc. We thank Narasimhan Gautam, Anna Glasgow, Kelly Hughes, Hong Ma, Mike Strathmann, Greg Wiederrecht, and Tom Wilkie for critical reading of the manuscript.

Additional details

August 19, 2023
October 17, 2023