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Published January 24, 2014 | Published + Supplemental Material
Journal Article Open

A Bio-Inspired Approach for the Reduction of Left Ventricular Workload


Previous studies have demonstrated the existence of optimization criteria in the design and development of mammalians cardiovascular systems. Similarities in mammalian arterial wave reflection suggest there are certain design criteria for the optimization of arterial wave dynamics. Inspired by these natural optimization criteria, we investigated the feasibility of optimizing the aortic waves by modifying wave reflection sites. A hydraulic model that has physical and dynamical properties similar to a human aorta and left ventricle was used for a series of in-vitro experiments. The results indicate that placing an artificial reflection site (a ring) at a specific location along the aorta may create a constructive wave dynamic that could reduce LV pulsatile workload. This simple bio-inspired approach may have important implications for the future of treatment strategies for diseased aorta.

Additional Information

© 2014 Pahlevan, Gharib. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Received: October 27, 2013; Accepted: December 19, 2013; Published: January 24, 2014. Author Contributions: Conceived and designed the experiments: NMP MG. Performed the experiments: NMP. Analyzed the data: NMP MG. Wrote the paper: NMP MG. Niema M. Pahlevan acknowledges support from the American Heart Association (AHA) Predoctoral fellowship (Award Id: 12PRE9610015). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Attached Files

Published - journal.pone.0087122.pdf

Supplemental Material - journal.pone.0087122.s001.doc

Supplemental Material - journal.pone.0087122.s002.zip


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August 19, 2023
August 19, 2023