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Published February 2005 | public
Book Section - Chapter Open

Complete gradient-LC-ESI system on a chip for protein analysis


This paper presents the first fully integrated gradient-elution liquid chromatography-electrospray ionization (LC-ESI) system on a chip. This chip integrates a pair of high-pressure gradient pumps, a sample injection pump, a passive mixer, a packed separation column, and an ESI nozzle. We also present the successful on-chip separation of protein digests by reverse phase (RP)-LC coupled with on-line mass spectrometer (MS) analysis.

Additional Information

© 2005 IEEE. Reprinted with Permission. Publication Date: 30 Jan.-3 Feb. 2005. Posted online: 2005-07-05. This work is supported in part by NSF ERC Center at Caltech (EEC-9402726) and NIH through grant 5Ro1 RR06217-10.


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