Published February 2005
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Complete gradient-LC-ESI system on a chip for protein analysis
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Abstract
This paper presents the first fully integrated gradient-elution liquid chromatography-electrospray ionization (LC-ESI) system on a chip. This chip integrates a pair of high-pressure gradient pumps, a sample injection pump, a passive mixer, a packed separation column, and an ESI nozzle. We also present the successful on-chip separation of protein digests by reverse phase (RP)-LC coupled with on-line mass spectrometer (MS) analysis.
Additional Information
© 2005 IEEE. Reprinted with Permission. Publication Date: 30 Jan.-3 Feb. 2005. Posted online: 2005-07-05. This work is supported in part by NSF ERC Center at Caltech (EEC-9402726) and NIH through grant 5Ro1 RR06217-10.Files
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Additional details
Identifiers
- Eprint ID
- 10444
- Resolver ID
- CaltechAUTHORS:XIEieeeicmems05
Funding
- NSF
- EEC-9402726
- NIH
- 5R01 RR06217-10
Dates
- Created
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2008-05-06Created from EPrint's datestamp field
- Updated
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2021-11-08Created from EPrint's last_modified field