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Published October 1, 2014 | Accepted Version + Supplemental Material + Published
Journal Article Open

Ru-based Z-selective metathesis catalysts with modified cyclometalated carbene ligands


A series of cyclometalated Z-selective ruthenium olefin metathesis catalysts with alterations to the N-heterocyclic carbene (NHC) ligand were prepared. X-Ray crystal structures of several new catalysts were obtained, elucidating the structural features of this class of cyclometalated complexes. The metathesis activity of each stable complex was evaluated, and one catalyst, bearing geminal dimethyl backbone substitution, was found to be comparable to our best Z-selective metathesis catalyst to date.

Additional Information

© 2014 The Royal Society of Chemistry. Received 26th May 2014. Accepted 3rd July 2014. First published online 03 Jul 2014. Research reported in this publication was supported by the National Institute of General Medical Sciences of the National Institutes of Health under award numbers F32GM102984 (fellowship to S.M.B.) and NIH R01-GM031332, the NSF under award number CHE-1212767, and the NSERC of Canada (fellowship to V.M.M.). NMR spectra were obtained by instruments supported by the NIH (RR027690). The Bruker KAPPA APEXII X-ray diffractometer was purchased via an NSF:CRIF:MU award to the California Institution of Technology (CHE-0639094). Lawrence Henling and Dr Michael Takase are acknowledged for X-ray crystallographic analysis. Naseem Torian and Dr Mona Shahgholi are acknowledged for high-resolution mass spectrometry assistance. Dr David VanderVelde is acknowledged for NMR assistance. Brendan Quigley, Dr Jeff Cannon, and Dr Daryl Allen are acknowledged for helpful discussions. David Weinberger (Bertrand Group) is gratefully acknowledged for providing CAACs. Materia, Inc. is thanked for its donation of 3 and metathesis catalysts 7 and 8.

Attached Files

Published - c4sc01541j.pdf

Accepted Version - nihms-614770.pdf

Supplemental Material - c4sc01541j1.pdf

Supplemental Material - c4sc01541j2.cif


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August 20, 2023
October 26, 2023