Welcome to the new version of CaltechAUTHORS. Login is currently restricted to library staff. If you notice any issues, please email coda@library.caltech.edu
Published April 4, 2006 | Accepted Version + Supplemental Material
Journal Article Open

Allocrine Modulation of Feeding Behavior by the Sex Peptide of Drosophila


Mating elicits a dramatic reprogramming of female behavior in numerous insect species. In Drosophila, this postmating response (PMR) comprises increased egg-laying rate and reduced sexual receptivity and is controlled by the products of the male accessory glands, a family of ∼80 small peptides transferred in the male seminal fluid [1-9]. Here, we show that copulation strongly stimulates female food intake. Remarkably, this change is abolished if the males lack a single, small seminal protein, the Sex Peptide (SP). Ectopic expression of SP in virgin females mimics the effect of mating on feeding behavior, demonstrating that SP is the main agent controlling this behavioral paradigm. Our observations identify enhanced feeding behavior as a novel component of the Drosophila PMR and suggest that SP represents a molecular link between energy acquisition and reproductive investment.

Additional Information

© 2006 Elsevier Ltd. Under an Elsevier user license. Received: December 8, 2005; Revised: February 14, 2006; Accepted: February 14, 2006; Published: April 3, 2006. We thank members of the Benzer lab, E. Kubli, and T. Aigaki for helpful discussions. This work was supported by a Lawrence L. and Audrey W. Ferguson Fellowship to G.B.C., a grant from the American Federation for Aging Research and a postdoctoral fellowship from the John Douglas French Foundation for Alzheimer's Research to P.K., and grants to S.B. from the National Institutes of Health (AG16630, AG24366, and DK070154), the National Science Foundation (MCB-0418479), and the Ellison foundation.

Attached Files

Accepted Version - nihms137889.pdf

Supplemental Material - mmc1.pdf


Files (483.8 kB)
Name Size Download all
65.5 kB Preview Download
418.3 kB Preview Download

Additional details

August 19, 2023
October 20, 2023