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Published June 2011 | public
Book Section - Chapter

Time-dependent cell membrane damage under mechanical tension: Experiments and modeling


This paper reports a study of cancer cell membrane damage during filtration caused by cell membrane tension. The membrane tension was induced when cells were captured on a microfabricated parylene-C filter during the constant-pressure-driven filtration. This work includes both experiments and modeling to explore the underlying biomechanics of the cell membrane damage. The developed model not only agrees with our time-dependent cell damage data, but also fits well with previous results on red blood cells reported by other groups.

Additional Information

© 2011 IEEE. This work is supported by the Caltech CII Award. PC-3 cancer cells were obtained from Dr. Amir Goldkorn's Lab in the Norris Cancer Center of University of Southern California.

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October 24, 2023