The synthesis of potential antimalarials. Derivatives of pantoyltaurine

Creators: Mead, J. F.; Rapport, M. M.; Senear, A. E.; Maynard, J. T.; Koepfli, J. B.

Abstract

The general hypothesis as to the mode of action of chemotherapeutic agents, which has been formulated by Fildes, Woods, McIlwain, and others (2), offers a rational and useful guide to the design of new drugs. Thus, bacteriostasis is pictured as caused by the blocking of reactions essential to growth by an inhibiting substance which has a structure similar to that of one of the normal enzymes or metabolites essential to the growth of the organism.

Additional Information

© 1946 American Society of Biological Chemists. Received for publication, January 22, 1946. The authors wish to thank Dr. William Trager of the Rockefeller Institute, Princeton, New Jersey, for his encouragement and suggestions and Dr. Carl Niemann and Dr. Edwin Buchman of this Institute for their advice and technical aid. We are indebted to Merck and Company, Inc., for a generous gift of l-pantolactone and 2-aminothiazole, to the American Cyanamid Company for a gift of 2-aminopyrimidine, and to Armour and Company for a gift of octadecylamine. The microanalyses, except where indicated, were performed by Dr. Gertrude Oppenheimer of this Institute. The work was done under a contract, recommended by the Committee on Medical Research, between the Office of Scientific Research and Development and the California Institute of Technology. The paper was submitted to the Advisory Committee on Publications, National Research Council, October 20, 1943. Gates and Crellin Laboratories of Chemistry, Contribution No. 949.

Attached Files

Published - MEAjbc46.pdf

Files

MEAjbc46.pdf

Files (618.8 kB)

Name	Size	Download all
MEAjbc46.pdf md5:4a5f526f579290f3ef5db03d24e31961	618.8 kB	Preview Download

Additional details

	All versions	This version
Views	0	0
Downloads	0	0
Data volume	0 Bytes	0 Bytes