Welcome to the new version of CaltechAUTHORS. Login is currently restricted to library staff. If you notice any issues, please email coda@library.caltech.edu
Published June 2017 | Accepted Version + Supplemental Material
Journal Article Open

Noninvasive Determination of Melanoma Depth using a Handheld Photoacoustic Probe


In this work, we propose applying photoacoustic tomography (PAT) to address this problem. Compared with traditional optical imaging methods, PAT uses ultrasonic waves, which give approximately 1,000 times less scattering than optical waves, breaking through the optical diffusion limit (∼1 mm in the skin) for penetration (Wang and Hu, 2012; Wang and Gao, 2014). In addition, by using optical excitation of acoustic waves due to light absorption, PAT provides improved contrast of melanin, which is deficient in ultrasonographic imaging. In previous mouse models, we measured a melanoma greater than 7 mm in depth (Zhou et al., 2015). Here we extend our work to patients with melanoma, with the aim of determining the accuracy of PAT-measured melanoma depth compared with the actual BD based on excisional biopsy results. In addition, we also compare our PAT measurement with the histologic measurement obtained from partial incisional biopsy to ultimately determine the predictability and application of PAT measurements in a clinical setting.

Additional Information

© 2017 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology. Accepted manuscript published online 3 February 2017. The authors would like to thank James Ballard for manuscript editing. This work was sponsored in part by National Institutes of Health grants DP1 EB016986 (NIH Director's Pioneer Award), R01 CA186567 (NIH Director's Transformative Research Award), and S10 RR026922. The authors state no conflict of interest. LVW has a financial interest in Microphotoacoustics, Inc., which, however, did not support this work.

Attached Files

Accepted Version - nihms962389.pdf

Supplemental Material - 1-s2.0-S0022202X17301045-mmc1.pdf


Files (508.5 kB)
Name Size Download all
182.2 kB Preview Download
326.3 kB Preview Download

Additional details

August 19, 2023
October 18, 2023