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Published August 21, 2015 | Accepted Version
Journal Article Open

Palladium-Catalyzed Asymmetric Conjugate Addition of Arylboronic Acids to α,β-Unsaturated Cyclic Electrophiles


This account describes our laboratory's efforts in the development of a palladium-catalyzed asymmetric conjugate addition of arylboronic acids to cyclic conjugate acceptors. Specifically, we highlight the study of this transformation in the following areas: (a) construction of all-carbon quaternary stereocenters, (b) elucidation of the reaction mechanism, (c) addition to heterocyclic acceptors to generate tertiary stereocenters, and (d) application in the synthesis of natural products.

Additional Information

© 2015 American Chemical Society. Received: May 28, 2015. Publication Date (Web): July 2, 2015. The authors thank the many past and present co-workers whose efforts have made our contributions in asymmetric conjugate addition possible: Michele Gatti, Emmett D. Goodman, Kotaro Kikushima, Bin Mao, Alexander N. Marziale, and Hideki Shimizu. Support for our program has been made available from the NIH-NIGMS (R01 GM080269), Amgen, and Caltech.

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August 20, 2023
October 23, 2023