Non ictal onset zone: A window to ictal dynamics

Abstract

The focal and network concepts of epilepsy present different aspects of electroclinical phenomenon of seizures. Here, we present a 23-year-old man undergoing surgical evaluation with left fronto-temporal electrocorticography (ECoG) and microelectrode-array (MEA) in the middle temporal gyrus (MTG). We compare action-potential (AP) and local field potentials (LFP) recorded from MEA with ECoG. Seizure onset in the mesial-temporal lobe was characterized by changes in the pattern of AP-firing without clear changes in LFP or ECoG in MTG. This suggests simultaneous analysis of neuronal activity in differing spatial scales and frequency ranges provide complementary insights into how focal and network neurophysiological activity contribute to ictal activity.

Additional Information

© 2017 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Received 23 May 2017, Revised 3 October 2017, Accepted 11 October 2017, Available online 21 October 2017. This work was supported by a Utah Research Foundation grant to BG. J. Egan for the action potential sorting. The authors wish to thank Dr. Bradley Greger for his helpful comments and review of this manuscript, Ms. Kristin Kraus for her editorial assistance, the EEG staff for their assistance in conducting this study, and most importantly the patient who participated selflessly in this research.

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Published - 1-s2.0-S2213323217300737-main.pdf

Supplemental Material - 1-s2.0-S2213323217300737-mmc1.pdf

Supplemental Material - 1-s2.0-S2213323217300737-mmc2.pdf

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