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Published February 24, 2009 | Published
Book Section - Chapter Open

In-vivo imaging of microcirculation using integrated photoacoustic and optical-coherence microscopy


Photoacoustic imaging and optical coherence tomography have complementary imaging contrasts. Photoacoustic imaging is sensitive to optical absorption, thus is able to generate detailed maps of deep microvasculature in vivo. Optical coherence tomography exploits the optical scattering contrast, and can provide real-time, micrometer-resolution imaging of tissue. We integrate an optical-resolution photoacoustic microscopy and a spectral-domain optical coherence tomography into a single system. Our preliminary experiments showed that it could be a valuable imaging tool for microcirculation studies in vivo.

Additional Information

© 2009 Society of Photo-Optical Instrumentation Engineers (SPIE). This work was sponsored in part by National Institutes of Health grants R01 CA092415, R01 NS46214 (BRP), R01 EB000712, R01 EB008085, and U54 CA136398 (NTR). L.W. has a financial interest in Endra, Inc., which, however, did not support this work.

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