Welcome to the new version of CaltechAUTHORS. Login is currently restricted to library staff. If you notice any issues, please email coda@library.caltech.edu
Published March 11, 1991 | public
Journal Article

A Schwann cell antigen recognized by monoclonal antibody 217c is the rat low-affinity nerve growth factor receptor


Monoclonal antibody 217c was generated against an antigen expressed on the rat glial cell line, C6 glioma. 217c has been shown to recognize Schwann cells in mixed cultures as well as in tissue sections and has been used to identify Schwann cells independent of other markers, such as monoclonal antibody 192-IgG, which recognizes the rat low affinity nerve growth factor (NGF) receptor. Here we show that the antigen recognized by 217c is the rat low-affinity NGF receptor. This indicates that monoclonal antibodies 192-IgG and 217c are not independent markers and therefore that additional criteria need to be used for the identification of Schwann cells early in development.

Additional Information

© 1991 Elsevier Scientific Publishers Ireland Ltd. Received 15 November 1990, Revised 3 December 1990, Accepted 5 December 1990. The authors would like to express their gratitude to Moses V. Chao for providing the LpMVR and Ltk-cell lines, to Jean de Vellis for providing the 217c antibody, to Eugene M. Johnson for providing the 192-IgG antibody and to Ms. Rochelle A. Diamond for the FACS analysis. This work is supported by NIH Grant NS-23476 and an NSF Presidential Young Investigator Award. D.J.A. is an Assistant Investigator of the Howard Hughes Medical Institute.

Additional details

August 22, 2023
October 20, 2023