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Published August 1963 | Published
Journal Article Open

Evidence for a ring structure of polyoma virus DNA


The DNA of polyoma (PY) virus has two interesting features: it is unusually resistant to heat or formamide denaturation,(1) and it has two distinct components, of sedimentation coefficient 14 and 21, respectively.(2) A two-component sedimentation was formerly shown to be a characteristic of the DNA of papilloma virus,(3) which is considered a member of the same group of viruses.

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© 1963 by the National Academy of Sciences. Communicated June 11, 1963. We are grateful to Prof. R.L. Sinsheimer for useful discussions. The competent and dedicated assistance of Miss Maureen Muir is gratefully acknowledged. This work will be supplemented by studies with the analytical ultracentrifuge.(17) Aided by grants from the National Institutes of Health, U.S. Public Health Service, the American Cancer Society, and The National Foundation.

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