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Published February 19, 2018 | Published
Book Section - Chapter Open

Linear-array based full-view high-resolution photoacoustic computed tomography of whole mouse brain functions in vivo


Photoacoustic computed tomography (PACT) is a non-invasive imaging technique offering high contrast, high resolution, and deep penetration in biological tissues. We report a photoacoustic computed tomography (PACT) system equipped with a high frequency linear array for anatomical and functional imaging of the mouse whole brain. The linear array was rotationally scanned in the coronal plane to achieve the full-view coverage. We investigated spontaneous neural activities in the deep brain by monitoring the hemodynamics and observed strong interhemispherical correlations between contralateral regions, both in the cortical layer and in the deep regions.

Additional Information

© 2018 Society of Photo-Optical Instrumentation Engineers. This work was funded by the National Institutes of Health (NIH) Grants U01 NS090579 (NIH Brain Initiative Award), U01 NS099717 (NIH Brain Initiative Award), R01 EB016963, DP1 EB016986 (Director's Pioneer Award), R01 CA186567 (Director's Transformative Research Award), S10 RR026922. The authors thank Prof. James Ballard for his close reading of the manuscript. L.V. Wang has a financial interest in Microphotoacoustics, Inc., CalPACT, LLC, and Union Photoacoustic Technologies, Ltd., which, however, did not support this work.

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