Published April 14, 2010
| Accepted Version + Supplemental Material
Journal Article
Open
Enantioselective Alkenylation via Nickel-Catalyzed Cross-Coupling with Organozirconium Reagents
- Creators
- Lou, Sha
-
Fu, Gregory C.
Abstract
A new family of organometallic compounds, organozirconium reagents, are shown to serve as suitable partners in cross-coupling reactions of (activated) secondary alkyl electrophiles. Thus, the first catalytic method for coupling secondary α-bromoketones with alkenylmetal reagents has been developed, specifically, a mild, versatile, and stereoconvergent carbon−carbon bond-forming process that generates potentially labile β,γ-unsaturated ketones with good enantioselectivity.
Additional Information
© 2010 American Chemical Society. Received February 28, 2010. Support has been provided by the National Institutes of Health (National Institute of General Medical Sciences, Grant R01-GM62871), Merck Research Laboratories, and Novartis. We thank Shaun D. Fontaine, Dr. Peter Mueller, and Dr. Michael R. Reithofer for assistance.Attached Files
Accepted Version - nihms189896.pdf
Supplemental Material - ja1017046_si_001.cif
Supplemental Material - ja1017046_si_002.pdf
Files
ja1017046_si_002.pdf
Additional details
- PMCID
- PMC2860276
- Eprint ID
- 102860
- DOI
- 10.1021/ja1017046
- Resolver ID
- CaltechAUTHORS:20200428-095146456
- NIH
- R01-GM62871
- Merck Research Laboratories
- Novartis
- Created
-
2020-04-29Created from EPrint's datestamp field
- Updated
-
2021-11-16Created from EPrint's last_modified field