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Published May 2010 | Published
Journal Article Open

Photoacoustic tomography of water in phantoms and tissue


Photoacoustic tomography (PAT) has been widely used to image optically absorptive objects in both human and animal tissues. For the first time, we present imaging of water with laser-based PAT. We photoacoustically measure the absorption spectra of water-ethanol mixtures at various water concentrations, and then image water-ethanol and pure-water inclusions in gel and a water inclusion in fat tissue. The significant difference in photoacoustic signals between water and fat tissue indicates that the laser-based PAT has the potential to detect water content in tissue.

Additional Information

© 2010 Society of Photo-Optical Instrumentation Engineers. Paper 10071R received Feb. 10, 2010; revised manuscript received Apr. 19, 2010; accepted for publication Apr. 20, 2010; published online Jun. 9, 2010. This work was sponsored in part by National Institutes of Health Grants R01 EB000712, EB000712A2S1, R01 EB00071207S2, R01 EB008085, R01 CA113453901, U54 CA136398, and 5P60 DK02057933. L.W. has a financial interest in Microphotoacoustics, Inc., and Endra, Inc., which, however, did not support this work.

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