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Published November 25, 1996 | public
Journal Article

Identification of Novel Paired Homeodomain Protein Related to C. elegans unc-4 as a Potential Downstream Target of MASH1


A novel paired homeodomain protein, PHD1, that is most closely related toC. elegansunc-4 has been identified by a differential RT–PCR method.PHD1is expressed in a narrow layer adjacent to the ventricular zone of the dorsal spinal cord, immediately following expression of MASH1 but preceding overt neuronal differentiation. Some cells coexpressing MASH1 andPHD1can be seen, suggesting that these two genes are sequentially activated within the same lineage. In the olfactory sensory epithelium,PHD1expression not only follows but is dependent upon MASH1 function, suggesting that PHD1 acts downstream of MASH1. A sequential action of bHLH and paired homeodomain proteins is apparent in other neurogenic lineages and may be a general feature of both vertebrate and invertebate neurogenesis.

Additional Information

© 1996 Academic Press. Received 7 June 1996, Accepted 11 September 1996, Available online 22 April 2002. This work was initiated in the laboratory of D.J.A. and completed at RIKEN. We thank Lukas Sommer for providing neurofilament probes. T.S. is a Special Researcher of the Basic Science Program at RIKEN. D.J.A. is an Associate Investigator of the Howard Hughes Medical Institute.

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