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Published June 2011 | Published
Journal Article Open

In vivo photoacoustic tomography of mouse cerebral edema induced by cold injury


For the first time, we have implemented photoacoustic tomography (PAT) to image the water content of an edema in vivo. We produced and imaged a cold-induced cerebral edema transcranially, then obtained blood vessel and water accumulation images at 610 and 975 nm, respectively. We tracked the changes at 12, 24, and 36 h after the cold injury. The blood volume decreased after the cold injury, and the maximum area of edema was observed 24 h after the cold injury. We validated PAT of the water content of the edema through magnetic Resonance Imaging and the water spectrum from the spectrophotometric measurement.

Additional Information

© 2011 SPIE. Paper 11073LRR received Feb. 16, 2011; revised manuscript received Apr. 9, 2011; accepted for publication Apr. 12, 2011; published online Jun. 1, 2011. This work was sponsored in part by National Institutes of Health Grant Nos. R01 EB000712, R01 EB008085, R01 CA134539, U54 CA136398, R01 EB010049, and 5P60 DK02057933. L.W. has a financial interest in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work.

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