Scaffold Proteins in the Postsynaptic Density
Many intractable neurological and mental diseases, including epilepsy, depression, and schizophrenia, are believed to result, in part, from derangements of regulation of synaptic transmission in the brain. For this reason, much effort has been made to discover how the delicate mechanisms of signal transduction at synapses lead to modification of synaptic strength. One fruitful area of research over the last twenty years has been the postsynaptic signaling apparatus in glutamatergic spines (8, 97, 99, 106). Spines contain clusters of receptors and signaling proteins located in a dense submembranous structure that can be seen in the electron microscope and is called the postsynaptic density or PSD (For review of early work see 98).
© 2008 Springer Science+Business Media, LLC. We thank the members of the Kennedy laboratory for many useful discussions. This work was supported by P.H.S. grants NS44306, NS17660, and NS028710 (MBK), and NS047894 (HJC); the Hereditary Disease Foundation (EM) and the Huntington's Disease Society of America (EM, MBK).