CaltechAUTHORS
Published December 2, 1999 | Version public
Journal Article Metadata-only

Synthesis of Trisubstituted Alkenes via Olefin Cross-Metathesis

Creators

Abstract

Trisubstituted alkenes have been prepared for the first time via intermolecular olefin cross-metathesis, using 1,3-dimesityl-4,5-dihydroimidazol-2-ylidene ruthenium alkylidene complexes 3a,b in good yields with moderate E selectivity. In addition, protected alcohols near the geminal disubstituted olefin improve reactivity for cross-metathesis.

Additional Information

© 1999 American Chemical Society. Received September 7, 1999. Publication Date (Web): November 2, 1999. Support has been generously provided by the National Institutes of Health. The authors thank Andrew G. Myers, Matthias Scholl, Thomas A. Kirkland, Helen E. Blackwell, and Daniel J. O'Leary for useful discussions and encouragement. The authors also wish to thank Richard Pederson for a generous supply of compound 8.

Additional details

Identifiers

Eprint ID
85375
DOI
10.1021/ol991023p
Resolver ID
CaltechAUTHORS:20180320-101056334

Related works

Describes
10.1021/ol991023p (DOI)

Funding

NIH

Dates

Created
2018-04-02
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Updated
2021-11-15
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