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Published 1985 | Published
Journal Article Open

The 68C Glue Puff of Drosophila


Drosophila melanogaster begins its life as a fertilized egg, which undergoes embryogenesis within an egg shell for about a day and then hatches from the egg as a first instar larva. The wormlike larva eats yeast for a day, then sheds its first instar skin and crawls out as a second instar larva. One day later another molt occurs, resulting in a third instar larva. The third instar stage lasts approximately 40 hours at 25 °C toward the end of this stage the larva crawls out of its medium and onto a dry surface. After a few hours of wandering, it stops, contracts, and secretes a protein glue from its salivary glands that hardens and attaches the larva to its substrate (Fraenkel and Brookes 1953). The affixed larva then tans its third larval instar cuticle into a puparial case, and some hours later pupates within this case. Complete metamorphosis follows pupation, and after several days the pupal case is opened and a new adult emerges.

Additional Information

© 1985 Cold Spring Harbor Laboratory Press. The Authors acknowledge that six months after the full-issue publication date, the Article will be distributed under a Creative Commons CC-BY-NC License (Attribution-NonCommercial 4.0 International License, http://creativecommons.org/licenses/by-nc/4.0/). Our 68C puff work has been funded by National Institutes of Health grant GM28075 to E.M.M., M.D.G., and P.H.M. are supported by National Research Service Award T32 GM07616; C.H.M. is supported by a National Science Foundation predoctoral fellowship; and K.V. is supported by a Procter and Gamble postdoctoral fellowship.

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August 19, 2023
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