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Published February 1, 2014 | Published
Journal Article Open

Spatially Fourier-encoded photoacoustic microscopy using a digital micromirror device

Abstract

We have developed spatially Fourier-encoded photoacoustic (PA) microscopy using a digital micromirror device. The spatial intensity distribution of laser pulses is Fourier-encoded, and a series of such encoded PA measurements allows one to decode the spatial distribution of optical absorption. The throughput and Fellgett advantages were demonstrated by imaging a chromium target. By using 63 spatial elements, the signal-to-noise ratio in the recovered PA signal was enhanced by ∼4×. The system was used to image two biological targets, a monolayer of red blood cells and melanoma cells.

Additional Information

© 2014 Optical Society of America. Received November 6, 2013; revised December 12, 2013; accepted December 15, 2013; posted December 16, 2013 (Doc. ID 200857); published January 20, 2014. The authors thank Lijun Ma, Yong Zhou, Chi Zhang, and Lei Li for helpful discussions and Professor James Ballard for close reading of the manuscript. This work was sponsored in part by National Institutes of Health grants DP1 EB016986 (NIH Director's Pioneer Award), R01CA134539, R01CA157277, and R01 CA159959. L. Wang has a financial interest in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work.

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