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Published December 1, 2011 | Published
Journal Article Open

Genetics of fat storage in flies and worms: what went wrong?


Body weight and fat storage are strongly influenced by an individual's genetic makeup. In humans, genetic polymorphisms have been identified that have effects on body mass index (BMI) and fat content (Meyre et al., 2009; Speliotes et al., 2010; Choquet and Meyre, 2011a), and studies of monogenic rodent models of obesity have defined a variety of genes and signaling pathways that control fat storage and metabolism (Barsh and Schwartz, 2002). However, many other genes that regulate these processes undoubtedly remain to be discovered. Although forward genetic screens in the mouse have the potential to identify new obesity genes, such screens are expensive and lengthy endeavors.

Additional Information

© 2011 Al-Anzi and Zinn. This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited. This article was submitted to Frontiers in Genomic Endocrinology, a specialty of Frontiers in Genetics. Received: 19 May 2011; accepted: 15 November 2011; published online: 01 December 2011.

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