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Published June 2015 | public
Book Section - Chapter

Measurement of viscosity of adult zebrafish blood using a capillary pressure-driven viscometer


This paper presents the first experimental work on the viscosity measurement of adult zebrafish whole blood using a capillary pressure-driven microfluidic viscometer. After the device calibration with water, the viscosity measurement of human whole blood was performed and in good agreement with published data, demonstrating the reliability of the device. Power law and Carreau-Yasuda rheological models were used to model the non-Newtonian behaviors of the human and zebrafish blood. Theoretical modeling and numerical algorithms were applied to determine the blood viscosity over a wide range of shear rates. The proposed approach is uniquely applicable for small sample volume (down to 1μL or less), and short measurement time (<3min). A wide range of shear rates is produced in a single test.

Additional Information

© 2015 IEEE. This work is supported by National Institutes of Health under award no. 7R01HL111437-03. The authors gratefully thank all the members of the Caltech Micromachining Lab and the UCLA Cardiovascular Engineering Research Laboratory for fruitful discussion.

Additional details

September 15, 2023
October 23, 2023