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Published March 11, 1988 | public
Journal Article

Regulation of Gene Expression by Interferons: Control of H-2 Promoter Responses


The magnitude of the response to interferons and the requirement for individual elements in the promoter of the H-2Dd gene were shown to be cell-specific and dependent on the type of interferon used. Three DNA sequences in the promoter were found to bind murine nuclear factors. Two of these sequences are in functionally defined enhancer regions and also bind to the transcription factor AP-1. The third sequence is part of the region involved in interferon regulation and is homologous to the enhancer element of the interferon beta gene. A model for interferon regulation of H-2 promoters is discussed.

Additional Information

© 1988 American Association for the Advancement of Science. Received 25 August 1987; accepted 31 December 1987. We thank K. Blackburn and M. Krempin for superb professional assistance with tissue culture, and D. Bohmann for advice during AP-1 purification. We thank M. Shepard of Genentech for providing the recombinant murine IFN γ, D. Vapnek of AMGen for human α consensus IFN, and T. Hansen for monoclonal antibodies. Supported by a National Research Service Award (T32GM7616) from the National Institute of General Medical Sciences and by an NIH grant AI 19624.

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