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Published October 1, 1997 | public
Journal Article

Ultrasound-modulated optical tomography of absorbing objects buried in dense tissue-simulating turbid media


Continuous-wave ultrasonic modulation of scattered laser light was used to image objects buried in tissue-simulating turbid media. The buried object had an absorption coefficient greater than the background turbid medium. The ultrasonic wave that was focused into the turbid media modulated the laser light that passed through the ultrasonic field. The modulated laser light that was collected by a photomultiplier tube reflected the local mechanical and optical properties in the zone of ultrasonic modulation. Objects buried in the middle plane of 5-cm-thick dense turbid media were imaged with millimeter resolution through the scanning and detecting alterations of the ultrasound-modulated optical signal. The optical properties of the dense turbid media included an absorption coefficient of 0.1 cm^(-1) and a reduced scattering coefficient of 10 cm^(-1) and were comparable with those of biological tissues in the visible and near-IR ranges. The dependence of the ultrasound-modulated optical signal on the off-axis distance of the detector from the optic axis and the area of the detector was studied as well.

Additional Information

© 1997 Optical Society of America. Received 10 January 1997; revised manuscript received 19 May 1997. This project was sponsored in part by the National Institutes of Health grant R29 CA68562 and The Whitaker Foundation.

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October 20, 2023