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Published August 2, 2006 | public
Journal Article

Area Expansion and Adsorption Isotherm in Protein Binding to Mixed Lipid Membranes


We present a thermodynamic analysis of protein adsorption to a mixed lipid monolayer containing a binding component and a nonbinding component at constant surface pressure. We derive the general equations for the adsorption isotherm and for the area expansion of the monolayer. In the limits of either low or high surface coverage, simplified forms of these equations are obtained. We construct simple thermodynamic models to examine the crossover from low to high surface coverage.

Additional Information

© 2006 American Chemical Society. Received 11 October 2005. Date accepted 23 January 2006. Published online 11 April 2006. Published in print 1 August 2006. The author wishes to thank Dan Pack and Frances Arnold for discussions, which led to this work.

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