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Published March 16, 2009 | Accepted Version
Journal Article Open

Micromachined "side-viewing" optical sensor probe for detection of esophageal cancers


In this paper, we report the design, fabrication and testing of a new miniaturized optical sensor probe with "side viewing" capability for oblique incidence diffuse reflectance spectrometry. The sensor probe consists of a lithographically patterned polymer waveguides chip and two micromachined positioning substrates and source/collection fibers to achieve 45° light incidence and collection of spatially resolved diffuse reflectance. Diffuse reflectance of human esophageal surface has been successfully measured for differentiation of cancerous tissues from normal ones.

Additional Information

© 2008 Elsevier B.V. Received 6 May 2008; Received in revised form 25 October 2008; Accepted 7 November 2008; Available online 25 November 2008. This project is partially supported by National Institutes of Health under contract R01 CA106728.

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Accepted Version - nihms117654.pdf


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