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Published June 2015 | Published
Journal Article Open

Multiview Hilbert transformation for full-view photoacoustic computed tomography using a linear array


Due to their low cost, hand-held convenience, wide selection of bandwidths, and ultrasound imaging capability, linear ultrasonic transducer arrays have been widely studied for photoacoustic computed tomography (PACT). As linear-array PACT suffers from a limited view, full-view imaging requires either the transducer or the object to be rotated. So far, both the central frequencies and bandwidth of linear transducer arrays applied in full-view PACT are low, limiting the spatial resolutions of the reconstructed images. Here, we present a multiview high-frequency PACT imaging system implemented with a commercial 40-MHz central frequency linear transducer array. By rotating the object through multiple angles with respect to the linear transducer array, we acquired full-view photoacoustic pressure measurements. Further, to quantify the unipolar initial pressures and overcome the limitations of the single-view Hilbert transformation, we developed a multiview Hilbert transformation method. The in-plane spatial resolution of this full-view linear-array PACT was quantified to be isotropically 60 μm within a 10×10  mm^2 field of view. The system was demonstrated by imaging both a leaf skeleton and a zebrafish in vivo.

Additional Information

© 2015 SPIE. Paper 150232R received Apr. 8, 2015; accepted for publication May 29, 2015; published online Jun. 25, 2015. The authors appreciate professor James Ballard's close reading of the manuscript and Stephen Cantor's assistance with zebrafish husbandry and preparation. This work was sponsored in part by National Institutes of Health (NIH) grants DP1 EB016986 (NIH Director's Pioneer Award), R01 CA186567 (NIH Director's Transformative Research Award), S10 RR026922, and R01 EB016963. L. V. Wang has a financial interest in Microphotoacoustics, Inc., and Endra, Inc., which, however, did not support this work.

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