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Published September 1995 | public
Journal Article

Budding of alphaviruses


The icosahedral structures of alphaviruses and of the external shell of the viral nucleocapsid have been defined to very high resolutions, revealing details of the interactions between the glycoproteins to form trimeric spikes, and between the spikes and the nucleocapsid. The structural studies complement biochemical and molecular genetic studies showing that a sequence-specific interaction between the cytoplasmic domains of the glycoproteins and the nucleocapsid drives budding.

Additional Information

© 1995 Elsevier Science Ltd. Our work is supported by grants AI 10793, AI 20612, AI 33982 and AI 35212 from the NIH.

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August 20, 2023
October 17, 2023