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Published December 10, 2007 | Published
Journal Article Open

An optical tweezer actuated, nanoaperture-grid based optofluidic microscope implementation method


We report a novel grid based Optofluidic Microscope (OFM) method where a closely spaced 2D grid of nanoapertures (diameter = 100 nm, separation = 2.5 μm) provided patterned illumination. We achieved a one-to-one mapping of the light transmissions through the nanoapertures onto a high-speed CCD camera. By optically tweezing a targeted sample across the grid in a controlled fashion and recording the time varying light reception from the nanoapertures, we were able to generate high-resolution images of the sample. The achievable resolution limit of the prototype was ~ 110 nm (Sparrow's criterion) under optimal conditions. We demonstrated the technique by imaging polystyrene beads and pollen spores.

Additional Information

© 2007 Optical Society of America. Received 12 September 2007; revised 5 November 2007; accepted 18 November 2007; published 26 November 2007. We thank Xiquan Cui, Jigang Wu and Lap Man Lee for helpful discussions. We are grateful to UCLA's Nanolab and Caltech's Molecular Materials Resource Center for giving us access to their equipment. This work was funded by DARPA Center for Optofluidic Integration (California Institute of Technology) and Coulter Foundation Early Career Award.

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