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Published November 1994 | metadata_only
Journal Article

SH2 and SH3 domains as molecular adhesives: the interactions of Crk and Abl


The Src homology domains SH2 and SH3 are modular components present in many signal transduction proteins. They allow rapid formation of stable protein complexes and may also regulate protein function through intramolecular binding events. SH2 domains recognize phosphotyrosyl residues in a specific sequence context, while SH3 domains recognize a PxxP motif and additional residues that mediate binding specificity.

Additional Information

© 1994 Published by Elsevier Ltd. We would like to thank our colleagues J. Groffen, G. Kruh, A. M. Pendergast and J. Y. J. Wang for contributing information before publication. We are especially grateful to A. Musacchio for the generous gift of Fig. 2, and to D. Cowburn and B. Knudsen for comments on the manuscript.

Additional details

August 20, 2023
August 20, 2023