Welcome to the new version of CaltechAUTHORS. Login is currently restricted to library staff. If you notice any issues, please email coda@library.caltech.edu
Published July 18, 2011 | Supplemental Material + Accepted Version
Journal Article Open

The Catalytic Enantioselective Total Synthesis of (+)-Liphagal


Ring a ding: The meroterpenoid natural product (+)-liphagal has been synthesized enantioselectively in 19 steps from commercially available materials. The trans-homodecalin system was achieved by ring expansion followed by stereoselective hydrogenation.

Additional Information

© 2011 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. Received: March 15, 2011; Article first published online: 10 June 2011. This publication is based on work supported by Award No. KUS-11-006-02, made by the King Abdullah University of Science and Technology (KAUST). We wish to thank the NIH-NIGMS (R01M080269-01), the Gordon and Betty Moore Foundation, Abbott, Amgen, Boehringer Ingelheim, and Caltech for generous funding. R.M.M. thanks Eli Lilly for a graduate fellowship. H.K. acknowledges the travelling scholarship of the Danish Technical University, the Jorcks foundation, and the Otto Mønsteds foundation for financial support. J.L.A. gratefully acknowledges the Amgen Foundation for funding through the Amgen Scholars program. We thank Prof. E. N. Jacobsen and Dr. S. J. Zuend for a kind donation of both (R)-t-leucine and their optimal Strecker catalyst.

Attached Files

Accepted Version - nihms377541.pdf

Supplemental Material - anie_201101842_sm_miscellaneous_information.pdf


Files (12.8 MB)
Name Size Download all
3.0 MB Preview Download
9.8 MB Preview Download

Additional details

August 22, 2023
October 23, 2023