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Published April 1947 | Published
Journal Article Open

Synthesis of hippuric acid in liver homogenate


The synthesis of hippuric acid from benaoic acid and glycine resembles in several respects the synthesis of a peptide bond. A CONH group is formed, it is a to a carboxyl group, and the free energy of its formation is of the same order of magnitude. The synthesis was demonstrated in liver and kidney slices of a number of animals; it is inhibited by 0.001 M KCN, which is in accord with the view that the necessary free energy is derived from an oxidation.(1)

Additional Information

© 1947 American Society of Biological Chemists. Received for publication, March 8, 1947. Carried out under Contract N6-ORI-102, Task Order No. 2, United States Navy Department.

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