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Published October 1, 2002 | Published
Journal Article Open

Ultrasound-modulated optical tomography of biological tissue by use of contrast of laser speckles


Ultrasound-modulated optical tomography based on the measurement of laser-speckle contrast was investigated. An ultrasonic beam was focused into a biological-tissue sample to modulate the laser light passing through the ultrasonic column inside the tissue. The contrast of the speckle pattern formed by the transmitted light was found to depend on the ultrasonic modulation and could be used for imaging. Variation in the speckle contrast reflected optical inhomogeneity in the tissue. With this technique, two-dimensional images of biological-tissue samples of as much as 25 mm thick were successfully obtained with a low-power laser. The technique was experimentally compared with speckle-contrast-based, purely optical imaging and with parallel-detection imaging techniques, and the advantages over each were demonstrated.

Additional Information

© 2002 Optical Society of America. Received 14 December 2001; revised manuscript received 18 April 2002. This project was sponsored in part by the National Institutes of Health grant R01 CA71980; the National Science Foundation grant BES-9734491; and the Texas Higher Education Coordinating Board grant 000512-0123-1999.

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