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Published March 4, 2013 | Supplemental Material
Journal Article Open

Practical and General Palladium-Catalyzed Synthesis of Ketones from Internal Olefins


Make it simple! A convenient and general palladium-catalyzed oxidation of internal olefins to ketones is reported. The transformation occurs at room temperature and shows wide substrate scope. Applications to the oxidation of seed-oil derivatives and a bioactive natural product (see scheme) are described, as well as intriguing mechanistic features.

Additional Information

© 2013 Wiley-VCH Verlag GmbH & Co. Issue published online: 27 Feb 2013. Article first published online: 16 Jan 2013. Manuscript Received: 28 Nov 2012. We thank Scott Virgil and the Caltech Center for Catalysis for technical assistance. We gratefully acknowledge financial support from King Abdullah University of Science and Technology Center in Development, King Fahd University of Petroleum and Minerals, the NSF, and the Swiss National Science Foundation for a fellowship to B.M.

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Supplemental Material - anie_201209541_sm_miscellaneous_information.pdf


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