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Published April 2017 | Published
Journal Article Open

Label-free high-throughput detection and quantification of circulating melanoma tumor cell clusters by linear-array-based photoacoustic tomography


Circulating tumor cell (CTC) clusters, arising from multicellular groupings in a primary tumor, greatly elevate the metastatic potential of cancer compared with single CTCs. High-throughput detection and quantification of CTC clusters are important for understanding the tumor metastatic process and improving cancer therapy. Here, we applied a linear-array-based photoacoustic tomography (LA-PAT) system and improved the image reconstruction for label-free high-throughput CTC cluster detection and quantification.

Additional Information

© 2017 Society of Photo-Optical Instrumentation Engineers. Paper 160583SSR received Aug. 24, 2016; accepted for publication Oct. 19, 2016; published online Nov. 10, 2016. The authors appreciate Professor James Ballard's close reading of the paper and Eric Zhang's assistance in cell cluster preparation. This work was sponsored by the National Science Foundation Grant No. 1255930 and the National Institutes of Health (NIH) Grant Nos. R01 CA186567 (NIH Director's Transformative Research Award) and S10 RR026922 (VSI). L. V. Wang has a financial interest in Microphotoacoustics, Inc., which, however, did not support this work.

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