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Published December 2007 | Supplemental Material
Journal Article Open

Photoacoustic Tomography of a Rat Cerebral Cortex in vivo with Au Nanocages as an Optical Contrast Agent


Poly(ethylene glycol)-coated Au nanocages have been evaluated as a potential near-infrared (NIR) contrast agent for photoacoustic tomography (PAT). Previously, Au nanoshells were found to be an effective NIR contrast agent for PAT; however, Au nanocages with their more compact sizes (<50 nm compared to >100 nm for Au nanoshells) and larger optical absorption cross sections should be better suited for in vivo applications. We sequentially injected Au nanocages into the circulatory system of a rat in three administrations and in vivo PAT was conducted immediately prior to the first injection and continued until 5 h after the final injection. A gradual enhancement of the optical absorption in the cerebral cortex, by up to 81%, was observed over the course of the experiment.

Additional Information

© 2007 American Chemical Society. Received September 12, 2007; Revised Manuscript Received November 4, 2007; Publication Date (Web): November 20, 2007. We thank Erich Stein for experimental assistance. This project was supported in part by the National Institutes of Health (NIH) Grants R01 NS46214 and R01 EB000712 (both to L.V.W.), as well as an NIH Director's Pioneer Award (5DP1OD000798) and a National Science Foundation Grant (DMR-0451788) (both to Y.X.). Z.Y.L. thanks the National Natural Science Foundation of China (Nos. 10525419 and 60736041) for financial support.

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Supplemental Material - nl072349rsi20070912_114308.pdf


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