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Published January 1, 2010 | Supplemental Material + Published
Journal Article Open

Label-free photoacoustic ophthalmic angiography


We present label-free functional photoacoustic imaging of the ocular microvasculature in living animals. The anterior segment of an adult mouse was imaged with a laser exposure level well within the American National Standards Institute safety standards. Individual red blood cells traveling along the iris capillaries were clearly resolved, and the hemoglobin oxygen saturation in the iris microvasculature was imaged spectrally. We believe that photoacoustic imaging has the potential to advance the diagnosis and treatment of ocular diseases in humans.

Additional Information

© 2010 Optical Society of America. Received September 10, 2009; revised November 15, 2009; accepted November 16, 2009; posted November 19, 2009 (Doc. ID 116816); published December 17, 2009. The authors appreciate Professor James Ballard's close reading of the manuscript. This work was sponsored by the National Institutes of Health (NIH) grants R01 EB000712, R01 NS46214, R01 EB008085, and U54 CA136398. L. V. Wang has a financial interest in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work.

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