Methods for diversifying protein structure

Abstract

By designing and expressing artificial genes, polymer chemists can prep. macromol. systems characterized by uniform chain length, sequence and stereochem. But the same mol. mechanisms that provide good control of chain architecture also limit the diversity of protein structure. This lecture will examine several complementary strategies for diversifying the products of cellular protein synthesis, including the incorporation of non-canonical amino acids, the prepn. of non-linear proteins, and programmed posttranslational modification.

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